background: diabetes mellitus is associated with cognitive deficits in humans and animals. these deficits are paralleled by neurophysiological and structural changes in brain. in diabetic animals, impairments of spatial learning, memory, and cognition occur in association with distinct changes in hippocampus, a key brain area for many forms of learning and memory and are particularly sensitive ...

human infection with echinococcus granulosis is a common disease throughout south america, the mediterranean littoral, the middle east, central asia and east africa, which usually occur in children and young adults. formation of avascular cystic lesions in the liver, kidney, pancreas, bones, vitreus and brain can cause protean of signs and symptoms. intracranial cysts usually present with focal...

we describe a 40-year-old woman presenting with headache, nausea, episodic amnesia and blurred optic disc. brain mri disclosed diffuse leptomeningeal enhancement. csf analysis showed aseptic meningitis with elevated ace level. neurosarcoidosis was diagnosed based on granulomatosis changes on tissue biopsy.

background & objectives: the accurate assessment of the diseased tissue is fundamental to the diagnosis and management of disorders of the central nervous system (cns). the ‛squash’ or ‛crush’ technique has been universally employed in the intraoperative diagnosis of cns tumors. the aim of our study was to evaluate the accuracy of squash preparation in diagnosing cns tumors by comparing wit...

thalamic pain syndrome, a type of central post-stroke pain (cpsp), may develops after a hemorrhagic or ischemic stroke and results in impairment of the thalamus. there is limited experience about gabapentin in treatment of central pains like cpsp.in a prospective observational study, the intensity of pain was recorded using the numeric rating scale (nrs) at the entrance to the study. patients e...

microglia is a type of glial cell located throughout the central nervous system (cns), which is sensitive to cns injury and disease. responsibility of microglia as the resident macrophage cells for injuries suggests that these cells have the potential to act as diagnostic markers of disease beginning or progression. function of microglia is strongly synchronized by the microenvironment of brain...

we present 16 years old girl with primary breast lymphoma involving the both breasts simultaneously and co-incidence of central nervous system (cns) involvement which originated from the breast, in addition to evidence of lymphoma in multi-organ such as skin, mediastinum and some abdominal viscera. bilaterality has been observed in some series, but reports are few and series are often very smal...

intracranial aspergilloma is extremely rare. the diagnosis and treatment of invasive cns aspergillosis is very difficult. early diagnosis is important for a successful treatment. here, we report a case of intracranial aspergilloma in an 11-year-old boy in 2013. good outcome was achieved by treatment with a combination of neurosurgical resection and antifungal administration, which we suggest is...

noncoding ribonucleic acids micro-rna is involved in the regulation of gene expression have major roles in the post-transcriptional level. a micro-rna alone several causes down regulation of mrna transcript of the target. thus, small changes in the expression of a micro rna may lead to significant changes in gene expression are different. micro- rna as key regulators of immune cell lineage diff...